Eda Cengiz
Yale School of Medicine, USA
Title: New Era in Diabetes Management: Artificial Pancreas Systems and Beyond
Biography
Biography: Eda Cengiz
Abstract
The incorporation of new technology into diabetes treatment provided diabetologists with additional tools like glucose sensors, smart insulin pumps, and the promise of closed loop insulin therapy (a.k.a the artificial pancreas project), a mechanical solution for diabetes management to restore near-physiologic glycemic control automatically. Such a system consists of three main elements: insulin delivery, continuous glucose sensing, and a controller or algorithm that, similar to the beta cell, regulates the proper amount of insulin delivery at the proper time. Advances in newer insulin formulations with improved pharmacokinetics (PK) and pharmacodynamics (PD) will galvanize closed loop insulin therapy systems and overcome challenges, such as late action of rapid acting insulins resulting in postprandial hyperglycemia. The Yale Pediatric Diabetes Center has been one of the main hubs of the artificial pancreas project and of research studies investigating the PK-PD of new insulin formulations. This talk will highlight the results of key studies in the field of diabetes technology including euglycemic clamp studies investigating the PK-PD of novel ultra fast acting insulins, the impact of innovative insulin delivery devices on insulin action, and the artificial pancreas project. It will discuss the barriers and limitations of this relatively nascent technology and solutions to overcome these challenges