Qunli Wu
Peking Union Medical College Hospital, China
Title: Jinmaitong capsule: An effective traditional Chinese medicine for the treatment of diabetic peripheral neuropathy
Biography
Biography: Qunli Wu
Abstract
Statement of the Problem: Up to 50% of patients with diabetes mellitus develop peripheral neuropathy. Painful peripheral neuropathy has a profound negative impact on quality of life and is one of the leading causes of non-traumatic lower limb amputations. The pathogenesis of diabetic peripheral neuropathy (DPN) remains unclear and there are no drugs known to halt or reverse the progression of DPN. The purpose of this study is to seek effective methods for the treatment of DPN from the traditional Chinese Medicine. Methodology & Theoretical Orientation: Guided by the thought of integrated traditional and western medicine, a long term study on the etiology, pathogenesis and syndrome characteristics of DPN is carried out. Then we developed the compound traditional Chinese medicine Jinmaitong capsule, and its clinical efficacy was verified. Findings: The syndrome of Yin-Yang deficiency with blood stasis is the most common syndrome differentiation type of DPN. The scores of neurological symptoms and signs were positively correlated with the scores of yin deficiency, Yang deficiency and blood stasis. The more severe Yang deficiency and blood stasis, the slower the conduction velocity of nerve. After treatment by Jinmaitong capsule, the scores of TCM symptoms and neurological function were obviously decreased, and the neurological symptoms and signs were improved. Furthermore, the abnormal parameters of nerve conduction velocity and sympathetic skin response test were also improved. JMT capsule can also reduce fasting and postprandial blood glucose, total cholesterol, triglyceride, whole blood viscosity and plasma viscosity, improve erythrocyte deformability, and reduce the activity of aldose reductase and the concentration of sorbitol, increase the activity of Na+/K+ -ATPase. The patients treated with Jinmaitong capsule had no definite adverse reactions during the medication. Conclusion & Significance: Chinese medicine Jinmaitong capsule is an effective and safe medicine for the treatment of DPN.